IV iron products (adults) - UpToDate You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. 1) Ganzoni AM. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Feraheme does not contain antimicrobial preservatives. PDF Venofer - Food and Drug Administration . For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Oral and parenteral products - see background option for oral products. Applies only to oral form of both agents. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. Recommended dosing and infusion rates for PI. 2000 Jan;22(1):39-43. Applies only to oral form of both agents. To view formulary information first create a list of plans. Do Not Copy, Distribute or otherwise Disseminate without express permission. Deferoxamine chelates iron. Avoid or Use Alternate Drug. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Applies only to oral form of both agents. Minor/Significance Unknown. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Administer Venofer early during the dialysis session (generally within the first hour). (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Last updated 28/06/2018 Enter values here and press 'Calculate'. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. Test Dose: Not required. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Iron Sucrose - Injection - Alberta Applies only to oral form of both agents. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. Adding plans allows you to compare formulary status to other drugs in the same class. Interaction only with oral iron administration. Applies only to oral form of both agents. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Ferric gluconate: 12.5 mg/mL. Separate by at least 4 hours. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Corrected Calcium. Nutrition. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. Applies only to oral form of both agents. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. Iron sucrose | Drugs | BNF | NICE Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Iron Sucrose Protocol - Cmqcc This website is intended for use by US healthcare professionals only. Before using, check this product visually for particles or discoloration. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Burns DL, Mascioli EA, Bistrian BR. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Applies only to oral form of both agents. Fatal reactions have followed the test dose of iron dextran injection. Assure stable intravenous access to avoid extravasation. https://www.uptodate.com/ (Requires subscription). Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. Treatment of anemia due to iron deficiency. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Separate dosing of tetracyclines from these products. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. commonly, these are generic drugs. Use Caution/Monitor. Copyright 1993-2021 Iron Deficit - Multi-Calc - GlobalRPH - Medical Calculators, Clinicians Use Caution/Monitor. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. You may need extra iron because of blood loss during kidney dialysis. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). Avoid or Use Alternate Drug. Dosage Calculator - [100% Free] - Calculators.io The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. This site complies with the HONcode standard for trust- worthy health information: verify here. Each mL contains 20 mg of elemental iron. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. If we don't have the calculator you need then tell us the details and we'll make it for you. Venofer (iron sucrose) dose, indications, adverse effects - PDR Venofer is given as an infusion into a vein. Avoid or Use Alternate Drug. Copyright 1993-2021 For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Applies only to oral form of both agents. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Applies only to oral form of both agents. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. Modify Therapy/Monitor Closely. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. Intravenous iron sucrose for children with iron deficiency anemia: a Learn how to store and discard medical supplies safely. Venofer must only be administered intravenously either by slow injection or by infusion. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. Venofer must only be administered intravenously either by slow injection or by infusion. There is in depth information below the form on the method used and on the result provided. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. Use Caution/Monitor. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Consult your pharmacist or local waste disposal company. PDF Iron dosing and administration in adults backgrounder Individual plans may vary If you log out, you will be required to enter your username and password the next time you visit. Applies only to oral form of both agents. Applies only to oral form of both agents. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Administer while the patient is in a reclined or semi-reclined position. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling (16.2).] Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Slowing the infusion rate may alleviate symptoms. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Use Caution/Monitor. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. This site complies with the HONcode standard for trust- worthy health information: verify here. Applies only to oral form of both agents. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. If we don't have the calculator you need we'll try to make it for you and add it to the website. Kumpf VJ. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. 1970;100(7):301303. Iron Product. Reference www.medicines.org.uk Background Applies only to oral form of both agents. Applies only to oral form of both agents. Parenteral iron dose - UpToDate Diagnosis and management of iron deficiency anaemia: a clinical update. Applies only to oral form of both agents. Canada residents can call a provincial poison control center. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. Minor/Significance Unknown.